Margarita Mamsirova was born in Russia. Her reprtoire includes Marina and the Inkeeper in Boris Godunov (Mussorgsky), Sonya in War and Peace, Smeraldina in L'amour des Trois Oranges (Prokofiev), Palina and Milavzor in Pique Dam (Tchaikovsky), the title role in La Cenerentola, Arscae in Semiramide, Isabella in L'Italiana in Algeri, Rosina in Il barbiere di Siviglia (Rossini), Dalila in Samson et Dalila (Saint-Saens), Laura in The Stone Guest (Dargomyzhsky) and many other roles. She performed at the opera houses of Paris, Macerata, Bologna, Barcelona, Warsaw, Riga and many others.

Her roles at the Israeli Opera:
Yevgeni Onegin: Olga (2013)